The major issue of this book is use of reproductive hormones and drugs in pregnant female animals because it was ignored for a long period. Obviously, there is not enough scientific research affords have been made in the area talk about the hazards of use of medical items in pregnant female farm animals so far globally. There for, there is not enough scientific literature concerning the establishment of adverse influence of use of these medical items on the development of the conceptus as early as 6 - 8 weeks from fertilization. However, in this unique scientific reference that discussed this controversial issue in the field of veterinary genecology, in the last offers concrete scientific evidence about the safety of injection (I.M or I.V) of Oxytetracycline during early or late pregnancy in cross-bred dairy cattle and Nubian goats in the Sudan. This research has been applied in the Faculty of Veterinary Medicine, University of Khartoum, Sudan (Mysaa, 2018, Maha, 2020 and Ahmed and Nahla, 2024).The practitioner's veterinarian, the undergraduate and postgraduate veterinary students can find enough scientific information about the indicated as well as contra-indicated use of drugs.