Based on the proceedings of the inaugural symposium "Northwest Symposium for Systems Biology". This book focuses on identifying technologies and their application to important model systems. It includes topics such as complex microbial systems, gene regulatory networks, molecular machines/multiprotein complexes and computational techniques.

1. Introduction.- Complex Microbial Systems.- 2. High-Throughout Techniques for Analyzing Complex Bacterial Communities.- Computational Methods.- 3. A Systems Approach to Discovering Signaling and Regulatory Pathways-or how to digest large interaction networks into relevant pieces.- 4. Genome Function-a virus-world view.- Molecular Machines: Multiprotein Complexes.- 5. Intracellular Proteolysis and Proteasomes.- 6. Conformational Switching in Muscle.- Gene Regulatory Networks.- 7. The Intricate Workings of a Bacterial Epigenetic Switch.- 8. Yeast Signal Transduction: Regulation and Interface with Cell Biology.